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    • Why do we need to do four-dimensional ultrasound?

    2025-03-12

    　　　　Obstetric examination is the necessary homework of pregnant mothers during pregnancy, many pregnant mothers pregnant to a certain period of time the doctor will let pregnant mothers go to do four-dimensional ultrasound, perhaps some pregnant mothers will think that usually have been regularly go to do the examination, four-dimensional ultrasound is not necessary to go to do it again, but in the birth of an unhealthy baby after the repentance of the beginning.　　Some pregnant mothers are wondering, what is 4D ultrasound? Why is it necessary to go for a 4D ultrasound during pregnancy and what are its functions? What should I pay attention to when I go to do ultrasound? Below, I will give you a detailed introduction. 　　What is four-dimensional color ultrasound　　The full name of four-dimensional color ultrasound is four-dimensional color ultrasound diagnostic instrument, is a modern advanced color ultrasound equipment. Four-dimensional color ultrasound is able to surface imaging, more clear screening of fetal limb development whether malformation, meningeal bulge, whether cleft lip and palate, spina bifida and other congenital anomalies, early detection and early solutions.　　The role of four-dimensional ultrasound for pregnant mothers and babies　　Determine the due date　　The best 4D ultrasound examination is recommended around the 22nd to 28th week of pregnancy, because during this period the structure of the fetus has been basically formed, the amniotic fluid is also well stocked, and the size of the fetus is developing just right, with more room for intrauterine activities, it is relatively easy for 4D ultrasound to capture, and the images are clearer, which makes it easier for the doctor to discover more developmental problems of the fetus in a timely manner.　　Checking the activity of the fetus　　It can check whether the fetus lacks oxygen in the uterus, limb movement, swallowing movement of the fetus, etc. It can see the activity…

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    Heavy research: in vitro resuscitation transfer, just need to add this drug surrogate mother live birth rate increased by 42%!

    2025-03-11

    　　　　With the resuscitation transplantation success rate increasing across the board, many surrogate mothers in IVF cycles prefer frozen embryo resuscitation transplantation, and in general for surrogate mothers who are able to ovulate on their own, doctors are more inclined to recommend the natural cycle.　　The natural cycle is more in line with the human body’s natural state of pregnancy, with a short medication time and very low dosage of medication. This programme is also particularly suitable for our circle sisters, as the reduction in the use of oestrogen can significantly reduce the risk of hypercoagulability. 　　Improving the live birth rate has always been a pain point for our surrogate mothers, Circle Sisters turned to a heavyweight study in Human and Reproduction last year, where they added only one drug to increase the live birth rate of surrogate mothers by 42%.　　I can’t wait to share it with you in hopes that it will help you who are entering your recovery cycle soon!　　01 Luteal Support Boosts Live Birth Rate Randomised Controlled Study　　It’s an already known fact that progesterone boosts live birth rates in surrogate mothers with early pregnancy preeclampsia, and progesterone is also required for frozen embryo transfers, but it’s generally used in artificial cycles.　　Generally natural cycles mimic the natural process of pregnancy and progesterone is not usually given for IVF, will natural cycle use boost pregnancy rates? This is the question this article is trying to answer. Between February 2013 and March 2018, a total of 500 subjects were randomly assigned to two 1:1 groups.　　Randomisation was carried out using opaque sealed envelopes after transfer of frozen embryos in natural cycles.　　The primary outcome was live birth rate; secondary outcomes were pregnancy, biochemical pregnancy, clinical pregnancy and miscarriage rates.　　From the date of embryo transfer, half of the subjects received vaginal progesterone administration at 100…

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    The real deal, your eggs are more savvy than you are!

    2025-03-10

    　　　　In the world of reproductive medicine, the birth and growth of each egg is full of mystery. As a reproductive physician, I am often struck by the egg’s amazing intelligence and ability to choose. Today, let’s unravel the mystery of the egg and see how it can be even smarter than we are in the ‘race’ of fertility. 　　In the female reproductive system, the egg is undoubtedly the bright star. Although women only produce one egg per month, this scarcity doesn’t make the egg a cool one. On the contrary, Miss Egg is like a graceful dancer who knows how to attract her suitor, the sperm.　　Instead of waiting quietly for the sperm to arrive, the study found that the egg actively releases chemicals that light a ‘beacon in the night’ for the sperm. These chemicals act like pheromones secreted by female moths, attracting male moths and guiding the sperm in the direction of the egg. In human female egg selection experiments, the number of sperm in the follicular fluid was almost 10 times higher than in the control solution, which proves the ‘guiding’ ability of the egg lady.　　Once the sperm are attracted to the ‘light’ of the egg, the next step is the intense selection process. In this session, Miss Egg is a strict examiner, scrutinising the sperm in the vicinity. She not only examines the speed and strength of the sperm, but also assesses their genetic quality.　　The follicular fluid not only attracts sperm, but also specifically selects them. This means that even though some sperm are fast, if they carry serious genetic defects, Miss Egg will still reject them without hesitation. This selection mechanism ensures that only those sperm that are strong, swift and genetically superior will have a chance to combine with the egg to form a fertilised…

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    Can single women freeze their eggs and who will protect their fertility?

    2025-03-08

    　Recently, a piece of news has aroused much debate among netizens, which suggests that single women should be given the right to implement assisted reproductive technology. 31-year-old Jess wanted to preserve and delay her fertility by freezing her eggs because of her job and age, but she was refused by the hospital because egg freezing is not open to single women in her home country. However, they were refused by the hospital because egg freezing is not open to single women in their home country. 　　‘Why is it that single men can save their sperm, but single women cannot freeze their eggs?’ Such a sentence resonates with many women, and also expresses the helplessness of many senior single women. So let’s talk about those things about egg freezing!　　Guarantee of Female Fertility　　The best age for women to have children is between 25-29 years old. After 30 years old, the function of the ovaries starts to decline, and so does the ability to have children naturally. Egg freezing (egg freezing technology), in order to prevent eggs from aging with the human body, removes the eggs when a woman is healthy and freezes them using cryopreservation technology, which not only preserves a woman’s fertility, but also slows down the latest time for a woman to have children. To a large extent, it protects a woman’s right to reproductive freedom and freedom of reproductive methods.　　Egg freezing for women abroad has become the norm　　Due to the restrictions on egg freezing for single women in their own countries, a large portion of women who have the need for egg freezing have to choose to spend a high amount of money to freeze their eggs abroad, where it has become the norm for single women to preserve their fertility through egg freezing.　　The rise of underground illegal egg…

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    Infertility 90 per cent have this problem! 4 misunderstandings and 3 key points of treatment, must get!

    2025-03-06

    　Infertility has become an unspeakable pain for many couples on the long road to pregnancy. Did you know? In fact, about 90% of infertility cases have a common problem, that is, ovulation disorder. However, many people have misconceptions about ovulation disorders and tend to overlook some key points in the treatment process. Today, let’s talk about these things related to ovulation disorders to help you clear the fog and find the right direction.　　First, what is ovulation disorder?　　Ovulation disorder, simply put, is a woman’s ovaries can not normally discharge eggs, or the quality of the eggs discharged is not good, and can not be successfully combined with the sperm to form a fertilised egg, thus affecting conception. It can be caused by a variety of reasons, such as dysfunction of the hypothalamic-pituitary-ovarian axis, polycystic ovary syndrome, premature ovarian failure, hyperprolactinaemia, and so on. It can be said that ovulation disorders are like a ‘barrier’ on the road to pregnancy, blocking many couples’ path to parenthood. 　　The 4 myths about ovulation disorder　　Myth 1: Normal menstruation must have normal ovulation　　Many women think that as long as they have regular menstrual periods, they will definitely be able to ovulate normally, and there is no problem of ovulation disorder. But in fact, normal menstruation is not the same as normal ovulation! Some women have regular periods, but they may have anovulatory menstruation, which means that the ovaries are only thickening and shedding their lining periodically, but they are not actually discharging eggs. For example, some patients with polycystic ovary syndrome have seemingly normal menstrual cycles, but ultrasound monitoring of follicular development and ovulation will reveal that there are no mature eggs to be discharged, which is typical of ovulation disorders that are ‘hidden’ under the appearance of seemingly normal menstruation.　　Myth 2: Ovulation is not a…

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    10 ways to improve egg quality with IVF

    2025-02-28

    　　The success rate of pregnancy is closely related to the quality of eggs. If the quality of eggs is not up to standard, the success rate will be greatly reduced. Clinically, there are many women who are repeatedly frustrated by poor egg quality, even with IVF, and this is especially true for women of advanced age.　　Recent studies have shown that poor lifestyle, diseases, age and other adverse effects on the mitochondria are important reasons for the decline in egg quality. Improving the function of the mitochondria may result in higher quality eggs and a more favourable pregnancy outcome.　　Mitochondria are ‘maternally inherited’. The mitochondria in a fertilised egg are all derived from the egg, and there are no mitochondria in the sperm. With age and the influence of external factors, the number of mitochondria will decrease and their function will deteriorate, which will cause the egg to be like a car without power, and it will easily break down, resulting in non-fertilisation, foetal termination, miscarriage and other phenomena. 　　So how to enhance mitochondrial function and improve oocyte quality?　　Diet:　　1. Eat more fresh fruits and vegetables　　Fresh fruits and vegetables are a great source of glutathione, which is a free radical scavenger that can help maintain the structure and function of mitochondria. Eating 6 to 9 measuring cups (1 measuring cup of 228 grams) of fresh vegetables and fruits every day is beneficial to your health, and we recommend a variety of green vegetables (cauliflower, brussels sprouts, etc.) and dark, brightly coloured vegetables (beets, carrots, etc.).　　2, intake of Ω3 fatty acids　　Omega 3 fatty acids are components of the mitochondrial membrane, consuming foods rich in Omega 3 fatty acids can help repair damaged mitochondrial membranes and improve mitochondrial function. Not only that, Omega 3 fatty acids can also reduce the inflammatory response and alleviate autoimmune…

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    Four IVF Transplant Failures, and What I Changed for the Fifth Time!

    2025-02-27

    At 37, I’m in the midst of my pregnancy journey. Many might wonder, what’s so challenging about having a baby at an older age? Well, first and foremost, getting pregnant becomes much more difficult compared to when you’re younger. Time is not on the side of the ovaries, and for the eggs, it’s like they’ve left home young and returned aged, with their vitality somewhat diminished. Let me share my story. I got married at 26 and spent the next 8 years focusing on my career. Once things were more stable, I decided it was time to start a family. But as I was already in my late 30s, despite a year of trying, I couldn’t conceive. So, I went to the fertility center at the hospital and underwent a series of tests: 7 – hormone panel, vaginal B – ultrasound, and semen analysis. The results showed that my AMH value was 0.8 ng/ml. On the doctor’s advice, I first took ovulation – stimulating injections and tried to conceive naturally. But a month later, my period came, and my natural pregnancy attempt failed. Given my age and the failed natural pregnancy, the doctor recommended first – generation IVF. After further examinations and some body – conditioning, I entered the IVF cycle. First Failure During the first egg retrieval, only 10 eggs were retrieved, and 4 of them successfully developed into blastocysts. After evaluating the blastocysts’ morphology, one embryo was graded 4BB. Unfortunately, the first embryo transfer ended in failure. Second Cycle: Still Unsuccessful My husband and I didn’t give up and entered the second cycle. In this cycle, 7 eggs were retrieved, and 5 transferable embryos were obtained. Over the next year or so, we had 3 embryo transfers, but one ended in failure, one in a chemical pregnancy, and…

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    Sex of the Baby: The Science and the Truth

    2025-02-27

    For parents-to-be, while looking forward to the healthy growth of their baby, they will inevitably wonder whether the little one in their tummy is a boy or a girl. So what determines the sex of a baby? Today, let’s delve deeper and unravel the mystery of your baby’s gender. Chromosomal Mechanisms that Determine SexHuman sex is determined by the XY sex chromosomes. Each body cell contains 23 pairs of chromosomes, of which 22 pairs are autosomes and the 23rd pair is the sex chromosome, which plays a key role in sex determination. The female sex chromosomes are homozygous, denoted by XX, while the male sex chromosomes are heterozygous, denoted by XY. The egg and sperm contain only half the number of chromosomes each, so the egg produced by a woman has a fixed chromosome form of 22+X, whereas the sperm produced by a man has two forms, 22+X and 22+Y respectively. When the egg is fertilised, it is reassembled into a new individual with 23 pairs of chromosomes, and it is completely random as to which sperm will unite with the egg. If a sperm with an X sex chromosome combines with the egg, the baby will develop into a girl; if a sperm with a Y sex chromosome combines with the egg, the baby will develop into a boy. Thus, the sex of the baby is actually determined by the sex chromosome carried by the sperm that fertilises the egg, which means that the father’s sperm plays a decisive role.Exploring the feasibility of human intervention in the sex of the baby In folklore, there are many ‘biased recipes’ that claim to determine the sex of a baby, such as ‘sour children’ and ‘changing the acidity or alkalinity of the internal environment’. But can these really intervene in the sex…

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    From scratch: Microscopic testicular sperm retrieval helps azoospermia patients

    2025-02-27

    As medical technology continues to develop, some people diagnosed with azoospermia now have the opportunity to have their own children without the help of a sperm bank. So how do they get sperm? This involves two common procedures: sperm retrieval by epididymal / testicular puncture and microscopic testicular sperm retrieval. Below, I will explain the difference between these two procedures in detail. Epididymal/testicular sperm aspirationFor patients with non-obstructive azoospermia, we use a simpler procedure called epididymal/testicular sperm aspiration. Specifically, a fine needle is used to puncture the epididymis or testis and remove a small amount of tissue to look for sperm and to determine the spermatogenic function of the testes. This method is relatively easy to perform but has some limitations.Microsperm extractionMicrosperm harvesting is known as microscopic sperm harvesting with an orchiectomy. This is a more delicate and minimally invasive procedure in which a small incision is made in the testicle, and then, with the aid of a microscope, we carefully search for possible spermatogenic vasculature. These selected tubules are then sent under a microscope at 20 times magnification to further search for sperm. This procedure greatly improves the accuracy and efficiency of sperm retrieval. If the sperm is successfully retrieved, it can be used for second generation IVF. Compared to traditional testicular sperm retrieval methods, microsperm retrieval has a relatively high rate of sperm acquisition. Differences in indications for the procedureIndications for epididymal / testicular sperm retrieval: mainly for patients with obstructive azoospermia. These patients have normal testicular spermatogenesis but are unable to expel sperm due to obstruction of the vas deferens. In such cases, sperm can usually be retrieved by epididymal/testicular puncture.Indications for microsperm retrieval: mainly for patients with non-obstructive azoospermia, i.e., those with problems with testicular spermatogenesis. Often, it is difficult to obtain sperm by epididymal/testicular puncture….

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