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    • Heavy research: in vitro resuscitation transfer, just need to add this drug surrogate mother live birth rate increased by 42%!

    2025-03-11

    　　　　With the resuscitation transplantation success rate increasing across the board, many surrogate mothers in IVF cycles prefer frozen embryo resuscitation transplantation, and in general for surrogate mothers who are able to ovulate on their own, doctors are more inclined to recommend the natural cycle.　　The natural cycle is more in line with the human body’s natural state of pregnancy, with a short medication time and very low dosage of medication. This programme is also particularly suitable for our circle sisters, as the reduction in the use of oestrogen can significantly reduce the risk of hypercoagulability. 　　Improving the live birth rate has always been a pain point for our surrogate mothers, Circle Sisters turned to a heavyweight study in Human and Reproduction last year, where they added only one drug to increase the live birth rate of surrogate mothers by 42%.　　I can’t wait to share it with you in hopes that it will help you who are entering your recovery cycle soon!　　01 Luteal Support Boosts Live Birth Rate Randomised Controlled Study　　It’s an already known fact that progesterone boosts live birth rates in surrogate mothers with early pregnancy preeclampsia, and progesterone is also required for frozen embryo transfers, but it’s generally used in artificial cycles.　　Generally natural cycles mimic the natural process of pregnancy and progesterone is not usually given for IVF, will natural cycle use boost pregnancy rates? This is the question this article is trying to answer. Between February 2013 and March 2018, a total of 500 subjects were randomly assigned to two 1:1 groups.　　Randomisation was carried out using opaque sealed envelopes after transfer of frozen embryos in natural cycles.　　The primary outcome was live birth rate; secondary outcomes were pregnancy, biochemical pregnancy, clinical pregnancy and miscarriage rates.　　From the date of embryo transfer, half of the subjects received vaginal progesterone administration at 100…

    Pregnancy rate increased by 12% after transplant, no injections or pills read this one enough!

    2025-03-11

    　　If you have had a transplant, I am sure whether this wait is 14 days or 7 days or 10 days, this is going to be very torturous and long and are you scratching your head wondering when you should test.　　The truth is that whether you test or don’t test doesn’t stop you from ruminating all the time, leading to fluctuations in your mindset and negative emotions affecting the blood supply to the uterus, leading to disturbed uterine contractions and thus affecting the embryo’s ability to settle in the womb.　　A lot of anxiety comes from the unknown, today the circle sister to transfer the third day of fresh embryo as an example, the embryo in the uterus every day ‘work’ to give you a list of clear instead of relaxation. 　　Some people say that I transferred the fifth day blastocysts, then you can start from the second three days of embryonic activities in this article, I will not be another blastocyst-related articles.　　Day one.　　It is transferred into the uterus as an eight or six cell embryo, at this point it doesn’t stay still in a fixed position, it floats, and if it is hungry, it will get its nourishment from the reserves of the blastocysts and the fluids in the mother’s cavity.　　At this point you will not have any discomfort other than some discomfort from the transfer procedure, such as a bloated belly and the like, and are encouraged to get out of bed as early as possible after the transfer to urinate.　　This is because there are clinical trials that have suggested that getting out of bed early to urinate has a tendency to increase the rate of attachment, and that early activity does not affect the position of the embryo or allow it to fall out as a result.　　Day Two　　After…

    I never thought that 77.1% of women’s success or failure of the test tube, but depends on this small step before transplantation!

    2025-03-11

    What do you need to pay attention to before transplantation, it is estimated that a thousand sisters have 10,000 kinds of views, some have a scientific basis, and some may be just rumours, the circle sister once gave some precautions before and after the transplantation, but it is not comprehensive.　　This article to say this precaution, it is estimated that nine out of ten sisters have not heard of, perhaps even the doctor has not been concerned about, but this really affects the success rate of pregnancy, so it must be said clearly. 　　Let me ask you a question: Has anyone ever checked their thyroid function before transplantation? I’m guessing very few of you can give an affirmative answer, it’s a matter of pregnancy success or failure.　　You may say, I have checked the thyroid gland is not a problem, but IVF itself can cause thyroid abnormalities, let’s take a look at what the literature says.　　01 IVF affects thyroid function　　This is a meta-analysis article published in the Journal of Assisted Reproduction and Genetics, the total sample size was 1,665 individuals, and the average TSH value at the end of the IVF was 2.53, which doesn’t seem high, but note that this is the average.　　What’s worse is that this state persisted, consistently above the threshold, for a full month, which corresponds to one month post-transplantation, severely impacting pregnancy success. 　Elevated TSH, commonly known as hypothyroidism, makes it difficult for a woman to get pregnant.　　If a woman becomes pregnant, her body is severely deficient in thyroxine, and the foetus relies on the mother’s supply of thyroxine, which can lead to miscarriage or serious malformation of the foetus.　　Even if pregnancy is successful, as thyroid function directly affects mental ability, hypothyroidism is likely to cause foetal retardation, mental retardation, preterm delivery, intrauterine foetal death, gestational toxicity,…

    Is third generation IVF the last straw for recurrent miscarriages? This fatal flaw cannot be ignored!

    2025-03-10

    　　　　Third-generation IVF is commonly referred to as embryos that have passed chromosome screening, and if there are no problems in the maternal environment, the chances of success after the transfer are higher than the success rate of pregnancy with embryos that have not been screened.　　But is this really the case? We found an authoritative evidence and share it with you!　　01Three-generation IVF you may not fully understand　　We all know that three-generation IVF is subject to chromosome screening, which is actually different, and for different groups of people, the screening is completely different.　　Triple IVF can be divided into three categories depending on what is being screened:　　The first type of screening is called PGT-A: this way can check whether the chromosomes of the embryo have more or less chromosomes, and such embryos may lead to miscarriage or birth defects.　　This technique is mainly suitable for people with advanced age and recurrent embryo abnormalities, and is equivalent to the original PGS technique.　　The second type of screening is called PGT-M: this way can check if the embryo has a specific single-gene genetic disease, such as thalassaemia, haemophilia, etc. Such genetic diseases may affect the child’s health and life expectancy.　　A healthy baby without specific gene carriers can be obtained in this way, which is equivalent to the original PGD technique.　　The third screening method is called PGT-SR. This method can check whether the chromosomes of the embryo are broken or stuck wrongly, which is actually the embryo chromosome balanced translocation screening technique.　　In addition, spinach, cabbage, mustard greens, leeks, amaranth, bamboo shoots and other foods rich in oxalic acid should not be taken with calcium, because oxalic acid in the intestinal tract can be combined with calcium to form an insoluble precipitate, affecting the absorption of calcium.　　How to take calcium supplements scientifically during pregnancy?　　Pregnant mothers have to be tested…

    The real deal, your eggs are more savvy than you are!

    2025-03-10

    　　　　In the world of reproductive medicine, the birth and growth of each egg is full of mystery. As a reproductive physician, I am often struck by the egg’s amazing intelligence and ability to choose. Today, let’s unravel the mystery of the egg and see how it can be even smarter than we are in the ‘race’ of fertility. 　　In the female reproductive system, the egg is undoubtedly the bright star. Although women only produce one egg per month, this scarcity doesn’t make the egg a cool one. On the contrary, Miss Egg is like a graceful dancer who knows how to attract her suitor, the sperm.　　Instead of waiting quietly for the sperm to arrive, the study found that the egg actively releases chemicals that light a ‘beacon in the night’ for the sperm. These chemicals act like pheromones secreted by female moths, attracting male moths and guiding the sperm in the direction of the egg. In human female egg selection experiments, the number of sperm in the follicular fluid was almost 10 times higher than in the control solution, which proves the ‘guiding’ ability of the egg lady.　　Once the sperm are attracted to the ‘light’ of the egg, the next step is the intense selection process. In this session, Miss Egg is a strict examiner, scrutinising the sperm in the vicinity. She not only examines the speed and strength of the sperm, but also assesses their genetic quality.　　The follicular fluid not only attracts sperm, but also specifically selects them. This means that even though some sperm are fast, if they carry serious genetic defects, Miss Egg will still reject them without hesitation. This selection mechanism ensures that only those sperm that are strong, swift and genetically superior will have a chance to combine with the egg to form a fertilised…

    Egg mitochondrial supplements, in the end, which are IQ tax, which efficient and practical

    2025-03-10

    　　　　Mitochondrial supplements, which we have covered in countless science articles, because mitochondria are so important to the egg, the circle has seen an investigation.　　To clarify the relationship between mitochondria and embryonic development, researchers collected human unfertilised oocytes, early embryos and embryos with arrested development.　　It was found that 67% of unfertilised oocytes had fewer mitochondria in the cytoplasm, and 60% of developmentally aborted embryos had a reduced number of mitochondria located near the nucleus.　　In oocytes, mitochondrial populations are maternally inherited and critical for developmental competence.　　Dysfunction of mitochondrial quality control mechanisms may lead to reproductive failure, and because of their central role in oocyte and embryo development, mitochondria have been described as a potential diagnostic and therapeutic target for assisted reproduction.　　The latest issue of Reproductive Global Topicals is also focusing on mitochondrial research and takes a look at the common mitochondrial supplements available on the market, so let’s follow along with the Topicals article and pick out the mitochondrial supplements that are best for you.　　01 Coenzyme Q10　　Coenzyme Q10 is mainly an electron transporter in the mitochondrial electron transport chain with antioxidant properties.　　Studies in mice, cattle, pigs and sheep have shown improved mitochondrial function after administration of Coenzyme Q10.　　Similarly, the addition of coenzyme Q10 to the embryo culture medium resulted in a significant increase in the maturation rate of advanced oocytes (82.6% vs 63.0%) and a decrease in the rate of oocyte aneuploidy (36.8% vs 65.5%).　　A study investigating follicular fluid from humans undergoing in vitro fertilisation cycles found that daily oral administration of coenzyme Q10 as a dietary supplement at a dose of 200 mg resulted in a significant increase in the active form of coenzyme Q10 in follicular fluid, an effect that was particularly pronounced in women aged 35 years and older.　　Elevated levels of coenzyme Q10 in follicular fluid were associated with…

    Nutritional Guidance for Expecting Mothers: A 2025 Guide to Optimizing Pregnancy Health

    2025-03-10

    Did you know that the nutritional status during the first 1,000 days of life significantly impacts fetal health throughout a person’s life? This crucial period spans from conception to two years after birth, with the fetal stage being particularly critical. 　　Research indicates that the metabolic systems established during the fetal phase remain unchanged throughout life. Therefore, the nutritional interventions provided during this time can greatly influence long-term health outcomes. If a child experiences malnutrition or adverse conditions during this period, the repercussions can include delayed physical and cognitive development, as well as an increased risk of obesity, diabetes, cardiovascular diseases, and various chronic illnesses in adulthood. Alarmingly, these effects can persist across multiple generations, highlighting the importance of proper nutritional supplementation during pregnancy and the fetal stage.　　Key Nutrients for Pregnancy: Essential Micronutrient Supplementation　　Women planning to conceive often have numerous questions about how to effectively supplement micronutrients during pregnancy. Here we outline some well-supported recommendations based on expert consensus.　　1. Folic Acid　　Routine genetic testing for folate metabolism isn’t necessary for most women. While not recommended for the general population, testing for serum or red blood cell folate concentrations is advisable for high-risk pregnant women—specifically those with a history of fetal neural tube defects. For women without risk factors, a daily supplementation of 0.4-0.8 mg of folic acid is recommended starting at least three months before conception and continuing through the first trimester. Opting for a multivitamin that includes folic acid, vitamin B12, and iron can further enhance health outcomes.　　For women who have experienced a prior neural tube defect pregnancy, a higher dosage of 4 mg of folic acid daily is suggested, beginning at least one month before conception and continuing through the third trimester.　　For those regrettably missing out on adequate nutritional supplementation prior to pregnancy, multivitamins containing at least three vitamins or…

    Can single women freeze their eggs and who will protect their fertility?

    2025-03-08

    　Recently, a piece of news has aroused much debate among netizens, which suggests that single women should be given the right to implement assisted reproductive technology. 31-year-old Jess wanted to preserve and delay her fertility by freezing her eggs because of her job and age, but she was refused by the hospital because egg freezing is not open to single women in her home country. However, they were refused by the hospital because egg freezing is not open to single women in their home country. 　　‘Why is it that single men can save their sperm, but single women cannot freeze their eggs?’ Such a sentence resonates with many women, and also expresses the helplessness of many senior single women. So let’s talk about those things about egg freezing!　　Guarantee of Female Fertility　　The best age for women to have children is between 25-29 years old. After 30 years old, the function of the ovaries starts to decline, and so does the ability to have children naturally. Egg freezing (egg freezing technology), in order to prevent eggs from aging with the human body, removes the eggs when a woman is healthy and freezes them using cryopreservation technology, which not only preserves a woman’s fertility, but also slows down the latest time for a woman to have children. To a large extent, it protects a woman’s right to reproductive freedom and freedom of reproductive methods.　　Egg freezing for women abroad has become the norm　　Due to the restrictions on egg freezing for single women in their own countries, a large portion of women who have the need for egg freezing have to choose to spend a high amount of money to freeze their eggs abroad, where it has become the norm for single women to preserve their fertility through egg freezing.　　The rise of underground illegal egg…

    What to choose between fresh, frozen and blastocyst embryos? The right one for you is the best!

    2025-03-08

    Blastocyst culture is another choice that many IVF families face after egg retrieval. There are various myths about blastocysts circulating among many IVF people, who believe that blastocysts are the best embryos, and that they should be taken to blastocyst culture as long as there are embryos available. 　　Firstly, let’s understand about cleavage stage embryos, blastocysts and frozen embryos　　Typically, when undergoing IVF to assist conception, we use ovulation stimulating drugs to promote the growth of a group of follicles, and when the eggs mature, they are removed through egg retrieval and combined with sperm in a petri dish to form an embryo. The embryo continues to develop outside of the body and is classified as a cleavage stage embryo or blastocyst depending on the number of days it has been developing.　　Cleavage stage embryo: The period of cellular mitosis that begins after the fertilisation of a spermatozoa and begins with the division of the syncytium into 2 cells and continues until the third day is called the ‘cleavage stage embryo’.　　Blastocyst: The cells of the cleavage stage embryo continue to divide and a blastocystic cavity begins to form between the cells, which is filled with fluid. After the formation of the blastocyst, the cells undergo their first differentiation, forming trophoblast ectodermal cells and endodermal cells. This is the 5th to 6th day of development of the fertilised egg.　　Embryo Freezing: In most cases, several transferable embryos can be formed in a single egg retrieval cycle, but only 1 or 2 embryos need to be transferred at a time, so the extra embryos will be frozen in liquid nitrogen at -196 degrees. Therefore, depending on whether the embryos are frozen or not, they are divided into ‘fresh embryos’ and ‘frozen embryos’.　　What are the common causes of endometritis?　　(1) Infection by microorganisms　　Under normal circumstances, the endometrium…

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