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    • Uterine Cavity Adhesion – A Roadblock on the Way to Pregnancy Preparation

    2025-02-28

    　　　　Uterine adhesion is a common gynaecological disease that seriously affects a woman’s fertility.　　The endometrium is the ‘soil’ where the fertilised egg takes root, the embryo is formed after the fertilisation of the sperm and the egg, and at the same time, the endometrium is actively preparing for the arrival of the embryo; when the development of the embryo and the endometrium are in the same pace, the blastocysts and the endometrium in a receptive state will be in further intimate contact, and the blastocysts will eventually burrow into the endometrial layer, and the embryo trophoblasts and the endometrial layer establish a close connection and begin to take root. The trophoblast layer of the embryo establishes a close relationship with the endometrium and begins to take root, which is embryo implantation. 　　Once the uterine cavity adhesion occurs, the missing endometrium will affect the fertilised egg to settle in the uterine cavity, leading to infertility; in addition, the lack of blood supply and hormonal support of the endometrium will not be able to provide sufficient nutrients for the embryo, leading to repeated failure of implantation of the embryo, embryonic arrest, miscarriage and other undesirable pregnancy outcomes.　　I. What is Uterine Adhesion?　　Uterine adhesion is a secondary endometrial disease in which multiple factors cause damage to the basal layer of the endometrium and fibrotic repair predominantly occurs. During the endometrial repair process, fibro-muscular adhesion bands are formed between the inner walls of the uterine cavity, which can lead to a smaller volume of the uterine cavity, abnormal uterine cavity morphology, and in severe cases, can lead to the closure of the uterine cavity.　　Histologically, adhesion of the uterine cavity shows the absence of normal endometrium, endometrial fibrosis, glands are covered by columnar epithelial cells without secretion function, some interstitium may be calcified or ossified, the glands…

    IVF Guide – Follicle Number ≠ Egg Number

    2025-02-28

    　　　　I believe that many IVF sisters have the same question, why is the number of follicles in the ultrasound examination different from the number of eggs obtained after the egg retrieval surgery? Are follicles equal to eggs? In fact, in the known part of the reason to see, IVF just in the egg retrieval link, may be damaged about 10%, can be very sure to tell you that the number of follicles does not represent the number of eggs retrieved. 　　So what is the reason for the high number of empty follicles found at egg retrieval? Today we will take you to find out.　　Follicle count ≠ actual number of eggs retrieved　　First of all, the number of follicles can be said to be the most concerned part of IVF sisters, because we often say that the number of basic follicles is directly related to the success rate of IVF. So how much difference will there be between the number of follicles monitored by ultrasound and the number of eggs retrieved in the end? Let’s take a look at the real feedback from three clients:　　Client A　　When I underwent follicle monitoring during ovulation, my doctor told me that the number of eggs I was eligible for retrieval through ultrasound was predicted to be only six. However, after going through the night shot and egg retrieval procedure, my egg retrieval result was 10, and the final result of the sac raising had 2 blastocysts of 4aa, and 1 successful implantation, which was a pleasant surprise for me.　　Client B　　When I did IVF for the first time, I went to a very famous public hospital. During the pre-checkup, the ultrasound examination showed that there were about 12 follicles on both sides of my body, but I didn’t realise that there were only 6 usable eggs retrieved…

    Why are more and more people choosing to go to Georgia for IVF?

    2025-02-28

    　　　　IVF in Georgia　　It is well known that IVF is a quality option for couples who desire to have a child but do not have the means to conceive naturally. However, even choosing IVF does not mean smooth sailing, and there are many cases where things do not go as well as they should, such as failed IVF attempts and long preparation for pregnancy. 　　In this case, travelling to Georgia for IVF has become a new ray of hope for many families who have failed IVF or who have been preparing for pregnancy for a long time. Georgia has won the trust of many families due to its advanced technology and scientific process, which is one of the reasons why more and more people choose to go to Georgia for IVF. Let’s take a comprehensive look at what are the outstanding advantages of IVF in Georgia.　　01　　World’s leading IVF success rate　　According to the World Medical Association, the success rate of IVF in Georgia can reach more than 80%. The high success rate data clearly conveys the professionalism of the facilities and the excellent technical skills of the assisted reproduction specialists.　　Reproductive hospitals in Georgia generally have advanced embryo laboratories, including micromanipulators, sac ring incubators, spindle observation systems, laser membrane breakers, CO2 incubators, PH meters, ICSI equipment, incubators, CodaAir air purification systems, etc., which guarantee the smooth running of the entire IVF operation.　　In addition to having advanced medical equipment, it is also indispensable to have highly responsible professional assisted reproduction specialists. When doing IVF in Georgia, the medication in the early stage is very strict, and the IVF experts will use the medication appropriately according to each patient’s physical condition. Subsequently, egg retrieval, sperm-egg binding, cystic ring screening, cystic ring transfer to successful pregnancy are all under the responsibility of one doctor, who monitors…

    Egg Freezing OR Embryo Freezing, What’s the Difference?

    2025-02-28

    　　　　Egg freezing or embryo freezing　　How to choose?　　Many IVF expectant parents will come across the situation of not having children for the time being but want to preserve their fertility, at this time, egg freezing or embryo freezing is the question of many expectant parents. Why is it that some women of similar age are recommended to undergo egg freezing while others are recommended to undergo embryo freezing? Which of the two has a higher success rate? …… These are some of the more popular questions, and today Jabra will analyse them in detail to see which one is suitable for your own situation. 　　Part1 Definition　　👉 Egg freezing: i.e. freezing eggs. It means that under the condition that the woman’s mother is healthy, through the doctor’s guidance to promote ovulation, the eggs are frozen to avoid the quality of eggs decreasing with the aging of the body. Frozen eggs are in a dormant state and will not continue to grow and develop, nor will they age over time, nor will their genetic material be affected. Eggs can be frozen for 1 year, 5 years, 10 years or even longer depending on your needs. When you want to have children, you can thaw the eggs and use them. It is important to note that the older a woman gets, the more her ovarian function declines and the number and quality of her eggs decreases significantly. There is little point in freezing and preserving problematic eggs, so it is recommended that women undergo egg freezing before the age of 35 to obtain a larger number of better quality eggs.　　👉 Frozen Embryos: i.e. frozen embryos. It means that after the doctor helps the mother-to-be to promote ovulation and retrieve eggs, the sperm eggs will be cultured into blastocysts, and the healthy embryos will be…

    Step 1 in Improving Fertility: Regulating Hormonal Balance

    2025-02-28

    When women planning for pregnancy want to assess their fertility, one of the essential tests is the six – hormone assay for sex hormones. Although it is a simple blood test, it can potentially reveal the reasons why a woman has long failed to conceive naturally or has experienced repeated failures in in – vitro fertilization (IVF). Today, TCC will guide you through understanding why we consider hormonal balance as the first step in enhancing fertility.

    Four IVF Transplant Failures, and What I Changed for the Fifth Time!

    2025-02-27

    At 37, I’m in the midst of my pregnancy journey. Many might wonder, what’s so challenging about having a baby at an older age? Well, first and foremost, getting pregnant becomes much more difficult compared to when you’re younger. Time is not on the side of the ovaries, and for the eggs, it’s like they’ve left home young and returned aged, with their vitality somewhat diminished. Let me share my story. I got married at 26 and spent the next 8 years focusing on my career. Once things were more stable, I decided it was time to start a family. But as I was already in my late 30s, despite a year of trying, I couldn’t conceive. So, I went to the fertility center at the hospital and underwent a series of tests: 7 – hormone panel, vaginal B – ultrasound, and semen analysis. The results showed that my AMH value was 0.8 ng/ml. On the doctor’s advice, I first took ovulation – stimulating injections and tried to conceive naturally. But a month later, my period came, and my natural pregnancy attempt failed. Given my age and the failed natural pregnancy, the doctor recommended first – generation IVF. After further examinations and some body – conditioning, I entered the IVF cycle. First Failure During the first egg retrieval, only 10 eggs were retrieved, and 4 of them successfully developed into blastocysts. After evaluating the blastocysts’ morphology, one embryo was graded 4BB. Unfortunately, the first embryo transfer ended in failure. Second Cycle: Still Unsuccessful My husband and I didn’t give up and entered the second cycle. In this cycle, 7 eggs were retrieved, and 5 transferable embryos were obtained. Over the next year or so, we had 3 embryo transfers, but one ended in failure, one in a chemical pregnancy, and…

    Can I still get pregnant with an AMH value of <1?

    2025-02-27

    “I have an AMH value of only 0.7. Can I still get pregnant?” Many patients often raise such questions. For women trying to conceive, one of the most concerning issues is abnormal hormone levels. So, what exactly does the AMH value reflect? And how much of an impact does it have on pregnancy? Let’s explore the topic of AMH today. What is AMH and What’s Its Function? AMH, also known as anti – Müllerian hormone, is secreted by the granulosa cells in the developing ovaries. It starts to be secreted when a female is still an infant. The greater the number of small follicles in the ovary, the higher the AMH value, which reaches its peak in late adolescence. From the reproductive age to just before menopause, eggs continuously grow, develop, ovulate, or undergo atresia. As a woman ages, the follicle reserve capacity declines, and the AMH concentration drops accordingly, until it becomes undetectable after menopause. Therefore, AMH can clearly reflect the ovarian function and evaluate a woman’s fertility. What to Do When AMH Value is Too Low? The normal range of AMH is 2 – 6.8 ng/ml. If the AMH value is too low, does it mean there is no hope of getting pregnant? Generally speaking, if it is lower than the normal range, it may indicate a decline in ovarian reserve capacity, with fewer follicles or no follicle formation. So, for women with a low AMH value, it is extremely difficult to conceive naturally. Many women try to find home remedies to increase their AMH value for the purpose of getting pregnant. In fact, ovarian decline is an irreversible natural phenomenon, and the AMH value cannot be increased. Instead of constantly seeking ways to raise the AMH value, it is better to accept the reality, seize the opportunity,…

    Sex of the Baby: The Science and the Truth

    2025-02-27

    For parents-to-be, while looking forward to the healthy growth of their baby, they will inevitably wonder whether the little one in their tummy is a boy or a girl. So what determines the sex of a baby? Today, let’s delve deeper and unravel the mystery of your baby’s gender. Chromosomal Mechanisms that Determine SexHuman sex is determined by the XY sex chromosomes. Each body cell contains 23 pairs of chromosomes, of which 22 pairs are autosomes and the 23rd pair is the sex chromosome, which plays a key role in sex determination. The female sex chromosomes are homozygous, denoted by XX, while the male sex chromosomes are heterozygous, denoted by XY. The egg and sperm contain only half the number of chromosomes each, so the egg produced by a woman has a fixed chromosome form of 22+X, whereas the sperm produced by a man has two forms, 22+X and 22+Y respectively. When the egg is fertilised, it is reassembled into a new individual with 23 pairs of chromosomes, and it is completely random as to which sperm will unite with the egg. If a sperm with an X sex chromosome combines with the egg, the baby will develop into a girl; if a sperm with a Y sex chromosome combines with the egg, the baby will develop into a boy. Thus, the sex of the baby is actually determined by the sex chromosome carried by the sperm that fertilises the egg, which means that the father’s sperm plays a decisive role.Exploring the feasibility of human intervention in the sex of the baby In folklore, there are many ‘biased recipes’ that claim to determine the sex of a baby, such as ‘sour children’ and ‘changing the acidity or alkalinity of the internal environment’. But can these really intervene in the sex…

    From scratch: Microscopic testicular sperm retrieval helps azoospermia patients

    2025-02-27

    As medical technology continues to develop, some people diagnosed with azoospermia now have the opportunity to have their own children without the help of a sperm bank. So how do they get sperm? This involves two common procedures: sperm retrieval by epididymal / testicular puncture and microscopic testicular sperm retrieval. Below, I will explain the difference between these two procedures in detail. Epididymal/testicular sperm aspirationFor patients with non-obstructive azoospermia, we use a simpler procedure called epididymal/testicular sperm aspiration. Specifically, a fine needle is used to puncture the epididymis or testis and remove a small amount of tissue to look for sperm and to determine the spermatogenic function of the testes. This method is relatively easy to perform but has some limitations.Microsperm extractionMicrosperm harvesting is known as microscopic sperm harvesting with an orchiectomy. This is a more delicate and minimally invasive procedure in which a small incision is made in the testicle, and then, with the aid of a microscope, we carefully search for possible spermatogenic vasculature. These selected tubules are then sent under a microscope at 20 times magnification to further search for sperm. This procedure greatly improves the accuracy and efficiency of sperm retrieval. If the sperm is successfully retrieved, it can be used for second generation IVF. Compared to traditional testicular sperm retrieval methods, microsperm retrieval has a relatively high rate of sperm acquisition. Differences in indications for the procedureIndications for epididymal / testicular sperm retrieval: mainly for patients with obstructive azoospermia. These patients have normal testicular spermatogenesis but are unable to expel sperm due to obstruction of the vas deferens. In such cases, sperm can usually be retrieved by epididymal/testicular puncture.Indications for microsperm retrieval: mainly for patients with non-obstructive azoospermia, i.e., those with problems with testicular spermatogenesis. Often, it is difficult to obtain sperm by epididymal/testicular puncture….

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